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iTIVA is a simulation program that provides information about distribution of drugs based on mathematical models and calculate a dose required to achieve a desired target, plasma or effect site concentration, like a TCI pump (target controlled infusion), calculating schemes that can be implemented in volumetric infusion pumps based on pharmacokinetics principles to guide your TIVA or balanced Anesthesia. So you can now easily do manual TCI

Pharmacokinetic models

iTIVA has 20 drugs and more than 33 pharmacokinetic models, that are updated continuously:

-Remifentanil - ULTIVA
-Fentanyl

-Hydromorphone
-Morphine
-Sufentanil

-Alfentanil

-Ketamine
-Procaine
-Lidocaine

-Propofol
 - DIPRIVAN
-Dexmedetomidine - PRECEDEX
-Midazolam

-Penthotal
-Atracurium
-Cisatracurium
-Vecuronium
-Rocuronium
-Tranexamic
-Magnesium Sulfate

It also calculate the end tidal (Et) for Isoflurane, Sevoflurane, Desflurane to get the MAC age based in the Mapleson formula or Lerou normogram and simulates bolus dosing.

iTIVA simulates the behavior of a TCI pump, calculating different infusion rates to achieve an effect site concentrations. When it placed in real time mode, iTIVA notifies when to make changes to the infusion.

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Created by David Ramirez, Cali - Colombia. Universidad de Valle. david@itiva.co

WARNING:
iTIVA is not designed to handle intravenous drugs for individual patients. Its use is limited to educational purposes to demonstrate pharmacokinetic principles when performing intravenous anesthesia. Therefore the user assumes all risks from the use of this application for clinical purposes.
Infusion schemes are obtained from concentrations based on models published in the medical literature; therefore concentrations achieved from these schemes can vary widely, in the same manner for clinical effects.
This application should only be used by people with extensive knowledge in Anesthesiology.

Keywords: anesthesiologist, anesthesia, physician, anesthetist, resident, fellow, IV, infusion, TCI, TIVA